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Synthesis Amphetamine: Chemical Composition and Applications


Amphetamine, a potent psychostimulant, is a synthetic substance that has been in use for several decades. Its chemical composition, synthesis, and applications have been a subject of intense study and investigation. This article aims to provide a comprehensive overview of the chemical structure, synthesis procedures, and applications of amphetamine synthesis amphetamine.

Chemical Composition of Amphetamine

Amphetamine, chemically known as (RS)-1-phenylpropan-2-amine, is a derivative of phenylpropanone with a substituted amino group. It has a molecular formula of C11H16NO and a molecular weight of 153.26 g/mol. Its chemical structure consists of a benzene ring, a side chain of two carbon atoms, and an amino group. The presence of a chiral carbon atom gives amphetamine two enantiomers: levo-(l)-amphetamine and dextro-(d)-amphetamine. These enantiomers have different physiological effects, with levo-amphetamine being the more potent of the two.

Synthesis of Amphetamine

The synthesis of amphetamine can be achieved through several methods, with the most common being the reductive amination of phenylpropanone. This process involves the reaction of phenylpropanone with a reducing agent, such as sodium borohydride or lithium aluminium hydride, in the presence of an amine or ammonia. The resulting imine or enamine undergoes reduction to form amphetamine.

Another common method for the synthesis of amphetamine is the Leuckart reaction. This method involves the reaction of phenylpropanone with formic acid and ammonia, resulting in the formation of amphetamine. This method is advantageous as it does not require the use of highly reactive reducing agents, reducing the risk of side reactions.

Applications of Amphetamine

Amphetamine has a wide range of applications due to its psychostimulant effects. It is used medically for the treatment of several conditions, including attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity. In the treatment of ADHD, amphetamine helps to improve focus and reduce impulsivity by increasing the levels of dopamine and norepinephrine in the brain. Similarly, in the treatment of narcolepsy, amphetamine reduces sleepiness by increasing the levels of these neurotransmitters. In the treatment of obesity, amphetamine acts as an appetite suppressant by increasing the levels of serotonin and dopamine in the brain.

In addition to its medical applications, amphetamine is also used recreationally. Its ability to increase focus and alertness, as well as produce feelings of euphoria, makes it a popular drug of abuse. However, its use as a recreational drug is associated with several risks, including addiction, cardiovascular problems, and psychosis.


Amphetamine, a synthetic substance with a complex chemical composition, has a wide range of applications due to its psychostimulant effects. Its synthesis involves the reduction of phenylpropanone, a compound that can be obtained from natural sources or synthesized. While amphetamine has several medical applications, its recreational use is associated with several risks. Therefore, its use should be monitored carefully to ensure its benefits outweigh its risks.

Note: This article is intended for informational purposes only. The use of amphetamine for non-medical purposes is illegal and punishable by law.

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